Cadcef O LB 200mg/200mg Tablet

Cadcef O LB 200mg/200mg Tablet is a combination of Cefixime, Ofloxacin, and Lactobacillus (Lactic Acid Bacillus). It is prescribed for bacterial infections caused by susceptible bacteria and may help reduce antibiotic-associated digestive discomfort.

Composition and Mechanism: Cadcef O LB 200mg/200mg Tablet contains Cefixime, a third-generation cephalosporin antibiotic, and Ofloxacin, a fluoroquinolone antibiotic, along with Lactobacillus (Lactic Acid Bacillus), a probiotic. Cefixime works by interfering with bacterial cell wall synthesis, while Ofloxacin works by blocking bacterial DNA replication, helping kill susceptible bacteria and control the infection. This combination is effective against a broad range of Gram-positive and Gram-negative bacteria including E. coli, Klebsiella. Lactobacillus helps restore beneficial gut

bacteria that may be reduced during antibiotic therapy, potentially lowering the risk of antibiotic-associated diarrhoea and digestive discomfort.

Major Therapeutic Uses: Cadcef O LB 200mg/200mg Tablet is commonly prescribed to treat bacterial infections such as respiratory tract infections such as flare-ups of chronic bronchitis and community-acquired pneumonia, throat infections (including pharyngitis and tonsillitis), sinusitis, ear infections, urinary tract infections (UTIs), typhoid fever, gastrointestinal infections, and certain mixed bacterial infections. It may also be prescribed for other susceptible bacterial infections based on the doctor’s assessment and local antibiotic sensitivity patterns.

Benefits, Precautions and Medical Supervision: This combination provides broad-spectrum antibacterial coverage and is well absorbed after oral administration. However, important precautions are necessary while using Cadcef O LB 200mg/200mg Tablet. The Ofloxacin component belongs to the fluoroquinolone group and has been associated with tendon inflammation (tendonitis) and, rarely, tendon rupture, especially in older adults and people using steroid medicines. Take this medicine exactly as prescribed and complete the full course even if symptoms improve early. This helps ensure proper treatment of the infection and reduces the risk of antibiotic resistance.

Cadcef O LB 200mg/200mg Tablet is prescribed for:

Respiratory Tract Infections

Such as bronchitis, flare-ups of chronic bronchitis, throat infections (tonsillitis/pharyngitis), sinusitis, and certain chest infections caused by susceptible bacteria.

Ear, Nose, and Throat (ENT) Infections

Helps treat ear infections (otitis media) and other bacterial ENT infections.

Urinary Tract Infections (UTIs)

Used in bacterial urinary infections such as cystitis and certain other UTIs, as prescribed by a doctor.

Typhoid Fever

May be prescribed in certain cases of typhoid fever caused by susceptible bacteria.

Gastrointestinal Infections

Used in certain bacterial intestinal infections and may help reduce antibiotic-associated diarrhoea due to the probiotic component.

Sexually Transmitted Infections (STIs)

May be prescribed in certain susceptible bacterial sexually transmitted infections as advised by a doctor.

• Broad-Spectrum Coverage: Effective against various Gram-positive and Gram-negative bacteria causing respiratory, urinary, gastrointestinal, ENT, and other bacterial infections.

• Dual Antibiotic Action: Cefixime and Ofloxacin work together to help control susceptible bacterial infections effectively.

• Supports Gut Health: Lactic Acid Bacillus helps restore beneficial intestinal bacteria that may be reduced during antibiotic therapy.

• Generally Well Tolerated: Most people tolerate it well when used as prescribed, with side effects usually being mild and temporary.

• Good Tissue Penetration: Ofloxacin helps the medicine reach infected tissues effectively, improving bacterial control in susceptible infections.

When taken as directed, Cadcef O LB 200mg/200mg Tablet is generally well tolerated. Side effects, if they occur, are usually mild and temporary.

Common Side Effects

• Diarrhoea or Loose Stools: Due to changes in normal gut bacteria.

• Nausea or Vomiting: Mild stomach upset may occur.

• Skin Rash: A mild rash may develop in some individuals.

• Loss of Appetite

• Abdominal Pain

• Headache or Dizziness

Uncommon Side Effects

• Allergic Reactions: Itching, rash, or hives (urticaria).

• Yeast Infections: Due to an imbalance of normal microbial flora.

• Elevated Liver Enzymes: Usually mild and reversible.

• Sleep Disturbance or Restlessness

Serious Side Effects (Require Immediate Medical Attention)

• Severe Allergic Reaction (Anaphylaxis): Difficulty breathing, swelling of the face, lips, or throat.

• Severe Skin Reactions: Such as blistering or peeling of skin.

• Tendon Pain or Swelling: Rarely, Ofloxacin may affect tendons

• Severe Dizziness, Confusion, or Seizures

• Persistent or Severe Diarrhoea: May indicate antibiotic-associated colitis.

• Severe Abdominal Pain or Vomiting: Especially if persistent.

• Cadcef O LB 200mg/200mg Tablet is available as tablets, and dry syrup/dry powder for oral suspension (commonly used in children).

• If this medicine is provided as a dry powder, add sterile water (provided in the pack, if available) or boiled and cooled water up to the marked line. Shake well to form a uniform suspension and shake before each use. Use a proper measuring device for accurate dosing.

• Take this medicine exactly as prescribed by your doctor, usually once or twice daily depending on the dose and severity of infection. It may be taken with or without food, although taking it with food may help reduce stomach discomfort.

• Complete the full course of treatment, even if you start feeling better early.

Cadcef O LB 200mg/200mg Tablet contains three active ingredients that work together to help treat bacterial infections and support gut health. Cefixime is a third-generation cephalosporin antibiotic that works by interfering with bacterial cell wall formation, causing the bacteria to weaken and die.

Ofloxacin is a fluoroquinolone antibiotic that works by blocking bacterial DNA replication, preventing bacteria from growing and multiplying. Together, Cefixime and Ofloxacin help control susceptible bacterial infections more effectively. Lactic Acid Bacillus (Lactobacillus) is a probiotic that helps restore and maintain the natural balance of beneficial bacteria in the intestine. Antibiotics may sometimes disturb normal gut flora (good bacteria in the intestine) and lead to diarrhoea or digestive discomfort. Lactobacillus helps support intestinal health and may reduce the risk of antibiotic-associated diarrhoea.

By combining these actions, the medicine helps treat bacterial infections while also supporting digestive balance during antibiotic therapy.

• Complete the full course: Take the medicine for the full duration prescribed, even if you feel better early.

• Do not skip doses: Missing doses can reduce effectiveness and may lead to antibiotic resistance.

• Take at regular intervals: Maintain evenly spaced dosing for best results.

• Take with food if needed: This may help reduce stomach discomfort.

• Inform your doctor of all medicines: Especially if you are taking other medications or have existing medical conditions.

• Tablets: Store in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep the medicine in its original packaging and out of reach of children.
• Dry Powder for Oral Suspension: Store the dry powder in a cool, dry place below 25°C and protect it from moisture and heat.
• After Reconstitution (Suspension): Keep the prepared suspension refrigerated (2–8°C) unless otherwise directed on the label. Do not freeze. Shake well before use and use within the recommended duration; discard any unused portion after that period.

• Alcohol (Caution): There is no major interaction, but alcohol may increase the risk of dizziness, stomach upset, or delay recovery. It is advisable to limit intake during treatment.

• Food: The medicine can generally be taken with or without food. Taking it after food may help reduce stomach discomfort.

• Antacids / Mineral Supplements: Products containing iron, calcium, magnesium, zinc, or aluminium may reduce the absorption and effectiveness of Ofloxacin.

• Blood Thinners (e.g., Warfarin): May increase the risk of bleeding.

• Anti-diabetic Medicines: Ofloxacin may affect blood sugar levels when used with diabetes medicines.

• Steroid Medicines (Corticosteroids): May increase the risk of tendon inflammation or tendon injury.

• NSAIDs (e.g., Ibuprofen, Diclofenac): Use cautiously, as fluoroquinolones like Ofloxacin may increase the risk of nervous system side effects such as tremors or seizures when taken with certain NSAIDs.

• Kidney Disease (Moderate to Severe): Dose adjustment may be needed in patients with impaired kidney function.

• Liver Disease (Caution): Use cautiously in severe liver impairment and under medical supervision.

• History of Seizures (Caution): Ofloxacin may increase the risk of dizziness, tremors, or seizures in susceptible patients.

• Myasthenia Gravis (Severe/Caution): Fluoroquinolones like Ofloxacin may worsen muscle weakness.

• History of Tendon Disorders (Caution): Use carefully in patients with previous tendon problems, especially in older adults or those taking steroids.

• Diabetes (Caution): Ofloxacin may rarely affect blood sugar levels. Use carefully in diabetic patients, especially those taking anti-diabetic medicines.

Always take this medicine exactly as prescribed. Taking more than the recommended dose may cause nausea, vomiting, diarrhoea, stomach pain, dizziness, confusion, or headache. In some cases, overdose may affect the nervous system or kidney function, especially in people with existing medical conditions.

If an overdose is suspected or symptoms become severe, seek medical attention immediately.

If you miss a dose of this antibiotic, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for it. Try to take doses at evenly spaced intervals, as missing doses can reduce effectiveness and may contribute to antibiotic resistance.