Amlodipine + Losartan is a combination medicine that contains Amlodipine and Losartan. It is used to treat high blood pressure (hypertension) in adults. Amlodipine relaxes and widens blood vessels by blocking calcium entry into the muscle cells of the heart and arteries. Losartan works by blocking the action of angiotensin II, a substance that tightens blood vessels and raises blood pressure.

By working together, these two medicines help lower blood pressure effectively and reduce strain on the heart. Taking Amlodipine + Losartan as prescribed, along with a healthy lifestyle, can help prevent serious complications such as heart attack, stroke, and kidney damage.

Amlodipine + Losartan combines amlodipine and losartan to provide effective and sustained blood pressure control through two complementary mechanisms. Each ingredient targets a different pathway involved in regulating blood pressure.

Amlodipine belongs to the class of calcium channel blockers. It works by inhibiting the movement of calcium into the smooth muscle cells of blood vessels. Calcium is required for muscle contraction; by reducing calcium entry, amlodipine relaxes blood vessels, allowing blood to flow more easily and lowering blood pressure. It also helps reduce chest pain (angina) by improving oxygen delivery to the heart.

Losartan belongs to the angiotensin II receptor blocker (ARB) class. Angiotensin II is a hormone that causes blood vessels to constrict and stimulates the release of aldosterone, leading to salt and water retention. Losartan blocks angiotensin II receptors, preventing these effects. As a result, blood vessels relax, blood pressure decreases, and excess fluid retention is reduced.

By combining a calcium channel blocker with an ARB, Amlodipine + Losartan provides enhanced blood pressure control compared to either medicine alone. This dual action not only lowers blood pressure but also protects vital organs such as the heart, brain, and kidneys from long-term damage caused by uncontrolled hypertension.

Hypertension (High Blood Pressure)

Management of elevated blood pressure in adults.

Cardiovascular Risk Reduction

Helps reduce the risk of stroke and heart attack associated with high blood pressure.

Angina (Chest Pain)

May help improve symptoms of angina due to improved blood flow.

Kidney Protection

Helps protect kidney function, especially in patients with hypertension and diabetes.

Dual-Action Blood Pressure Control

Combines two effective mechanisms to achieve better BP control.

Heart Protection

Reduces strain on the heart and lowers the risk of heart-related complications.

Stroke Prevention

Helps reduce the risk of stroke associated with uncontrolled hypertension.

Kidney Support

Losartan provides protective benefits for kidney health.

Improved Tolerability

Combination therapy may reduce the need for higher doses of a single medicine.

Convenience

Two medicines in one tablet improve adherence and simplify treatment.

Most side effects are mild and temporary. However, some reactions may occur.

Common Side Effects:

• Dizziness or light-headedness

• Swelling of ankles or feet (peripheral oedema)

• Headache

• Fatigue

• Flushing

Uncommon Side Effects:

• Low blood pressure (hypotension)

• Nausea

• Palpitations

• Mild increase in potassium levels

Serious Side Effects (Require Immediate Medical Attention):

• Severe allergic reactions: Swelling of face, lips, throat, or difficulty breathing

• Severe hypotension: Fainting or extreme dizziness

• High potassium levels (Hyperkalaemia): Muscle weakness, irregular heartbeat

• Kidney problems: Reduced urine output or swelling

Amlodipine + Losartan should be taken exactly as prescribed by your doctor, usually once daily. It can be taken with or without food. Swallow the tablet whole with a glass of water. Take it at the same time every day for best results.

Do not stop taking the medicine suddenly without consulting your doctor, even if you feel well, as high blood pressure often has no symptoms.

Amlodipine + Losartan lowers blood pressure through the complementary actions of amlodipine and losartan.

Amlodipine blocks calcium channels in the smooth muscle of blood vessels. This prevents calcium from entering the cells, causing the blood vessels to relax and widen. As a result, blood pressure decreases and blood flow improves.

Losartan blocks angiotensin II receptors. Angiotensin II normally causes blood vessels to constrict and promotes fluid retention. By blocking its action, losartan relaxes blood vessels and reduces fluid buildup, further lowering blood pressure.

Together, these mechanisms provide sustained blood pressure control and reduce the risk of cardiovascular complications.

• Take the medicine regularly at the same time each day.

• Monitor your blood pressure at home and maintain a record.

• Avoid excessive salt intake and follow a heart-healthy diet.

• Rise slowly from sitting or lying positions to reduce dizziness.

• Inform your doctor if you experience persistent swelling or severe dizziness.

• Stay hydrated, especially during hot weather

• Inform your healthcare provider about all other medicines you are taking

• Do not stop treatment abruptly without medical advice.

• Alcohol (MODERATE): May increase dizziness and lower blood pressure excessively.

• High-Salt Diet (NEGATIVE EFFECT): May reduce the effectiveness of blood pressure control.

• Potassium Supplements/Potassium-Sparing Diuretics (MODERATE): May increase risk of high potassium levels.

• Other Antihypertensives (MODERATE): May enhance blood pressure–lowering effect.

• NSAIDs (MODERATE): May reduce effectiveness and affect kidney function.

• Lithium (MODERATE): Risk of increased lithium levels and toxicity.

• Kidney Disease (MODERATE): Requires monitoring of kidney function and potassium levels.

• Liver Disease (MODERATE): Dose adjustment may be necessary.

• Hyperkalaemia (MODERATE): Losartan may increase potassium levels.

• Heart Failure (CAUTION): Use under medical supervision.

If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue your regular schedule.

Do not take two doses at the same time to make up for a missed one.