Azithromycin + Cefixime + Lactic Acid (Lactobacillus) is an antibiotic and probiotic combination used to treat a wide range of bacterial infections. It contains Azithromycin and Cefixime, which help fight infection-causing bacteria, along with Lactobacillus (Lactic Acid Bacillus), a beneficial probiotic that helps restore healthy gut bacteria and may reduce antibiotic-associated diarrhoea. It is commonly prescribed for infections of the respiratory tract, urinary tract, gastrointestinal tract, typhoid fever, certain sexually transmitted bacterial infections, and other susceptible bacterial infections. This combination provides broad-spectrum antibacterial coverage against many Gram-positive and Gram-negative bacteria. The probiotic component helps support the body’s natural microbial balance during antibiotic therapy.

Azithromycin + Cefixime + Lactic Acid (Lactobacillus) is a combination of Azithromycin, Cefixime, and Lactobacillus (Lactic Acid Bacillus). It is prescribed for bacterial infections caused by susceptible bacteria and may help reduce antibiotic-associated digestive discomfort.

Composition and Mechanism: Azithromycin + Cefixime + Lactic Acid (Lactobacillus) contains Azithromycin, a macrolide antibiotic, and Cefixime, a third-generation cephalosporin antibiotic, along with Lactobacillus (Lactic Acid Bacillus), a probiotic. Azithromycin works by inhibiting bacterial protein synthesis, while Cefixime works by interfering with bacterial cell wall synthesis, helping control and eliminate susceptible bacteria. This combination is effective against a broad range of Gram-positive and Gram-negative bacteria. Lactobacillus helps restore beneficial gut bacteria that may be reduced during antibiotic therapy, potentially lowering the risk of antibiotic-associated diarrhoea and digestive discomfort.

Major Therapeutic Uses: Azithromycin + Cefixime + Lactic Acid (Lactobacillus) is commonly prescribed to treat bacterial infections such as respiratory tract infections including bronchitis and community-acquired pneumonia, throat infections (including pharyngitis and tonsillitis), sinusitis, urinary tract infections (UTIs), typhoid fever, gastrointestinal infections, certain sexually transmitted bacterial infections, and other susceptible mixed bacterial infections. It may also be prescribed for other bacterial infections based on the doctor’s assessment and local antibiotic sensitivity patterns.

Benefits, Precautions and Medical Supervision: This combination provides broad-spectrum antibacterial coverage and is generally well absorbed after oral administration. The addition of Lactobacillus helps support intestinal microbial balance during antibiotic therapy. Take Azithromycin + Cefixime + Lactic Acid (Lactobacillus) exactly as prescribed and complete the full course even if symptoms improve early. This helps ensure proper treatment of the infection and reduces the risk of antibiotic resistance. Use this medicine only under medical supervision, especially in patients with liver, kidney, or gastrointestinal conditions.

Respiratory Tract Infections

Such as bronchitis, throat infections (tonsillitis/pharyngitis), sinusitis, and certain chest infections caused by susceptible bacteria.

Ear, Nose, and Throat (ENT) Infections

Helps treat ear infections (otitis media) and other bacterial ENT infections.

Urinary Tract Infections (UTIs)

Used in certain bacterial urinary infections as prescribed by a doctor.

Typhoid Fever

May be prescribed in certain cases of typhoid fever caused by susceptible bacteria.

Gastrointestinal Infections

Used in certain bacterial intestinal infections. The probiotic component may help support gut flora during antibiotic therapy.

Sexually Transmitted Infections (STIs)

Used in certain bacterial STIs such as gonorrhoea.

• Broad-Spectrum Infection Control: Helps fight a wide range of bacterial infections effectively.

• Dual Antibiotic Action: Azithromycin and Cefixime work together to improve bacterial coverage.

• Faster Symptom Relief: May help reduce fever, throat pain, cough, and infection-related discomfort.

• Useful in Mixed Infections: Effective when multiple types of bacteria may be involved.

• Gut Protection Support: Lactobacillus helps maintain healthy intestinal bacteria during antibiotic use.

• Long Tissue Retention: Azithromycin stays in body tissues for a longer duration, allowing prolonged antibacterial action even after the dose is completed.

• Short Course Therapy: Azithromycin remains active in the body for a longer time, so it is often prescribed for a shorter treatment duration compared to many other antibiotics.

When taken as directed, Azithromycin + Cefixime + Lactic Acid (Lactobacillus) is generally well tolerated. Side effects, if they occur, are usually mild and temporary.

Common Side Effects

• Diarrhoea or Loose Stools: Due to changes in normal gut bacteria.

• Nausea or Vomiting: Mild stomach upset may occur.

• Skin Rash: A mild rash may develop in some individuals.

• Loss of Appetite

• Abdominal Pain

• Headache or Dizziness

• Taste Changes: Temporary change in taste sensation may occur.

Uncommon Side Effects

• Allergic Reactions: Itching, rash, or hives (urticaria).

• Yeast Infections: Due to an imbalance of normal microbial flora.

• Elevated Liver Enzymes: Usually mild and reversible.

• Sleep Disturbance or Restlessness

Serious Side Effects (Require Immediate Medical Attention)

• Severe Allergic Reaction (Anaphylaxis): Difficulty breathing, swelling of the face, lips, or throat.

• Severe Skin Reactions: Such as blistering or peeling of skin.

• Severe dizziness or confusion (rare)

• Persistent or Severe Diarrhoea: May indicate antibiotic-associated colitis.

• Severe Abdominal Pain or Vomiting: Especially if persistent.

• Liver Problems: Yellowing of the skin or eyes, dark urine, or severe fatigue.

• Azithromycin + Cefixime + Lactic Acid (Lactobacillus) is commonly available as tablets for oral use.

• Take this medicine exactly as prescribed by your doctor, usually once or twice daily depending on the dose, severity of infection, and your medical condition.

• Swallow the tablet whole with a glass of water. Do not crush or chew it unless advised by your doctor.

• It can be taken with or without food, although taking it after food may help reduce stomach discomfort.

• Complete the full course of treatment even if symptoms improve early. Do not skip doses or stop the medicine on your own, as this may lead to treatment failure or antibiotic resistance.

Azithromycin + Cefixime + Lactic Acid (Lactobacillus) contains three active ingredients that work together to help treat bacterial infections and support gut health. Cefixime is a third-generation cephalosporin antibiotic that works by interfering with bacterial cell wall synthesis, so that, without a cell wall, bacteria cannot survive and eventually weaken and die.

Azithromycin is a macrolide antibiotic that works by inhibiting bacterial protein synthesis, thereby stopping bacteria from growing and multiplying. Together, Cefixime and Azithromycin provide broad-spectrum antibacterial coverage and help control susceptible bacterial infections more effectively.

Lactic Acid Bacillus (Lactobacillus) is a probiotic that helps restore and maintain the natural balance of beneficial bacteria in the intestine. Antibiotics may sometimes disturb the normal gut flora (good bacteria in the intestine), leading to diarrhoea or digestive discomfort. Lactobacillus helps support intestinal health and may reduce the risk of antibiotic-associated diarrhoea.

By combining these actions, the medicine helps treat bacterial infections while also supporting digestive balance during antibiotic therapy.

• Complete the full course: Take the medicine for the full duration prescribed, even if you feel better early.

• Do not skip doses: Missing doses can reduce effectiveness and may lead to antibiotic resistance.

• Take at regular intervals: Maintain evenly spaced dosing for best results.

• Take with food if needed: This may help reduce stomach discomfort.

• Inform your doctor of all medicines: Especially if you are taking other medications or have existing medical conditions.

Store in a cool, dry place below 25°C, away from direct sunlight, heat, and moisture. Keep the medicine in its original packaging and out of reach of children.

• Alcohol (Caution): There is no major direct interaction, but alcohol may increase the risk of stomach upset, dizziness, or weakness. It is advisable to limit alcohol intake during treatment.

• Food: The medicine can generally be taken with or without food. Taking it after food may help reduce stomach discomfort.

• Antacids / Mineral Supplements: Products containing calcium, magnesium, aluminium, iron, or zinc may reduce antibiotic absorption and effectiveness.

• Blood Thinners (e.g., Warfarin): May increase the risk of bleeding; monitoring may be required.

• Heart Rhythm Medicines: Medicines used for arrhythmias may increase the risk of irregular heartbeat when taken with Azithromycin.

• Other Antibiotics or Strong Medicines Affecting the Liver: May increase the risk of side effects or liver problems.

• Probenecid: May increase Cefixime levels in the body.

• Kidney Disease (Moderate to Severe): Dose adjustment may be needed in patients with impaired kidney function, especially due to Cefixime.

• Liver Disease (Caution): Use cautiously in patients with liver impairment and under medical supervision, as Azithromycin is processed mainly by the liver.

• Heart Rhythm Disorders (Caution): Azithromycin may rarely affect heart rhythm (QT prolongation). Use carefully in patients with existing heart rhythm problems or electrolyte imbalance.

• History of Colitis / Severe Diarrhoea (Caution): Antibiotics may rarely cause severe diarrhoea or antibiotic-associated colitis.

Always take this medicine exactly as prescribed. Taking more than the recommended dose may cause nausea, vomiting, diarrhoea, stomach pain, headache, dizziness, or weakness. In some cases, overdose may affect the liver, kidney function, or heart rhythm, especially in people with existing medical conditions.

If an overdose is suspected or symptoms become severe, seek medical attention immediately.

If you miss a dose of this antibiotic, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for it. Try to take doses at evenly spaced intervals, as missing doses can reduce effectiveness and may contribute to antibiotic resistance.