Cefixime + Cloxacillin + Lactic Acid (Lactobacillus) is an antibacterial medicine containing Cefixime, Cloxacillin, and Lactobacillus (Lactic Acid Bacillus). It is used to treat various bacterial infections affecting the respiratory tract, throat, ears, skin, urinary tract, and other susceptible body tissues. Cefixime has good activity against many Gram-negative bacteria. Cloxacillin provides added protection against Gram-positive bacteria such as Staphylococcus species. The addition of Lactobacillus helps maintain the natural balance of healthy intestinal bacteria during antibiotic treatment and may help reduce stomach upset or antibiotic-associated diarrhoea.

Composition and Mechanism: Cefixime + Cloxacillin + Lactic Acid (Lactobacillus) contains Cefixime, Cloxacillin, and Lactobacillus (Lactic Acid Bacillus). Cefixime is a third-generation cephalosporin antibiotic that works by interfering with bacterial cell wall synthesis, leading to the destruction of susceptible bacteria. Cloxacillin, a penicillin-class antibiotic, remains effective against certain penicillin-resistant Staphylococcus species that produce penicillinase enzymes. Lactobacillus helps maintain the natural balance of beneficial intestinal bacteria during antibiotic therapy and may help reduce antibiotic-associated stomach upset or diarrhoea.

Major Therapeutic Uses: Cefixime + Cloxacillin + Lactic Acid (Lactobacillus) is commonly prescribed to treat bacterial infections such as respiratory tract infections including bronchitis and certain bacterial chest infections; ear, nose, and throat (ENT) infections including otitis media and sinusitis; skin and soft tissue infections such as cellulitis, infected wounds, and abscesses; and urinary tract infections (UTIs) including cystitis. It may also be prescribed for other susceptible bacterial infections based on the doctor’s assessment and local antibiotic sensitivity patterns.

Benefits, Precautions and Medical Supervision: This combination offers antibacterial coverage against both Gram-positive and Gram-negative bacteria. The addition of Lactobacillus may help improve gastrointestinal tolerance during antibiotic treatment. Take this medicine exactly as prescribed and complete the full course even if symptoms improve early. Stopping treatment too soon may lead to incomplete infection control and increase the risk of antibiotic resistance. It should not be used in patients who are allergic to penicillins, cephalosporins, or any ingredient of the formulation. Use with caution in patients with liver impairment or a history of antibiotic-associated liver problems.

Respiratory Tract Infections

Such as bronchitis, and certain bacterial chest infections caused by susceptible bacteria.

Ear, Nose, and Throat (ENT) Infections

Helps treat bacterial ear infections (otitis media) and sinus infections (sinusitis).

Skin and Soft Tissue Infections

Used in certain skin infections such as cellulitis, infected wounds, boils, or abscesses, especially where Staphylococcus species may be involved.

Urinary Tract Infections (UTIs)

Used in certain bacterial urinary infections such as cystitis and uncomplicated urinary tract infections.

Post-surgical wound infections

Aids in faster recovery and healing.

• Broad Antibacterial Coverage: Helps treat a variety of bacterial infections caused by both Gram-positive and Gram-negative bacteria.

• Faster Symptom Relief: May help reduce fever, throat pain, swelling, and infection-related discomfort as the infection improves.

• Useful in Mixed Bacterial Infections: Beneficial when infections caused by multiple types of bacteria are suspected.

• Gut Flora Support: Lactobacillus helps maintain beneficial intestinal bacteria during antibiotic treatment and may reduce antibiotic-associated diarrhoea or stomach upset.

• Additional Staphylococcal Coverage: Cloxacillin provides added activity against certain Staphylococcus species, including some penicillinase-producing strains.

When taken as directed, Cefixime + Cloxacillin + Lactic Acid (Lactobacillus) is generally well tolerated. Side effects, if they occur, are usually mild and temporary.

Common Side Effects

• Diarrhoea or Loose Stools: Due to changes in normal gut bacteria.

• Nausea or Vomiting: Mild stomach upset may occur.

• Skin Rash: A mild rash may develop in some individuals.

• Loss of Appetite

• Abdominal Pain

• Headache or Dizziness

Uncommon Side Effects

Allergic Reactions: Itching, rash, or hives (urticaria).

Yeast Infections: Due to an imbalance of normal microbial flora.

Elevated Liver Enzymes: Usually mild and reversible.

Serious Side Effects (Require Immediate Medical Attention)

• Severe Allergic Reaction (Anaphylaxis): Difficulty breathing, swelling of the face, lips, or throat.

• Severe Skin Reactions: Such as blistering or peeling of skin.

• Persistent or Severe Diarrhoea: May indicate antibiotic-associated colitis.

• Severe Abdominal Pain or Vomiting

• Liver Problems: Yellowing of the skin or eyes, dark urine, or severe fatigue.

• Cefixime + Cloxacillin + Lactic Acid (Lactobacillus) is commonly available as tablets for oral use.

• Take this medicine exactly as prescribed by your doctor, usually once or twice daily depending on the dose. The dose and duration of treatment depend on the patient’s age, severity of infection, and medical condition.

• Swallow the tablet whole with a glass of water. Do not crush or chew it unless advised by your doctor.

• It can be taken with or without food, although taking it after food may help reduce stomach discomfort.

• Complete the full course of treatment even if symptoms improve early. Do not skip doses or stop the medicine on your own, as this may lead to treatment failure or antibiotic resistance.

Cefixime + Cloxacillin + Lactic Acid (Lactobacillus) contains three active ingredients that work together to help treat bacterial infections and support gut health. Cefixime is a third-generation cephalosporin antibiotic that works by interfering with bacterial cell wall synthesis. Without a proper cell wall, susceptible bacteria weaken and eventually die. Cloxacillin is a penicillin-class antibiotic that also interferes with bacterial cell wall formation and remains effective against certain penicillinase-producing Staphylococcus species. Together, Cefixime and Cloxacillin provide broader antibacterial coverage against susceptible Gram-positive and Gram-negative bacteria.

Lactic Acid Bacillus (Lactobacillus) is a probiotic that helps restore and maintain the natural balance of beneficial intestinal bacteria. Antibiotics may sometimes disturb normal gut flora, leading to diarrhoea or digestive discomfort. Lactobacillus helps support intestinal health and may reduce the risk of antibiotic-associated diarrhoea.

By combining these actions, the medicine helps treat bacterial infections while also supporting digestive balance during antibiotic therapy.

• Complete the full course: Take the medicine for the full duration prescribed, even if you feel better early.

• Do not skip doses: Missing doses can reduce effectiveness and may lead to antibiotic resistance.

• Take at regular intervals: Maintain evenly spaced dosing for best results.

• Inform your doctor of all medicines: Especially if you are taking other medications or have existing medical conditions.

Store in a cool, dry place below 25°C, away from direct sunlight, heat, and moisture. Keep the medicine in its original packaging and out of reach of children.

There are no known major food interactions with this medicine. It may be taken with or without food. Taking it after food may help reduce stomach discomfort.

• Antacids / Mineral Supplements: Products containing calcium, magnesium, aluminium, iron, or zinc may reduce antibiotic absorption and effectiveness. A gap between doses may be recommended.

• Blood Thinners (e.g., Warfarin): May increase the risk of bleeding; monitoring may be required.

• Probenecid: May increase Cefixime levels in the body.

• Kidney Disease (Moderate to Severe): Dose adjustment may be needed in patients with impaired kidney function, especially due to Cefixime.

• Liver Disease (Caution): Use cautiously in patients with liver impairment and under medical supervision, as prolonged antibiotic use may increase the risk of liver-related side effects.

• Allergy to Penicillins or Cephalosporins (Contraindication): This medicine should not be used in patients with a history of allergy to penicillins, cephalosporins, or related antibiotics.

• History of Colitis / Severe Diarrhoea (Caution): Antibiotics may rarely cause severe diarrhoea or antibiotic-associated colitis.

Always take this medicine exactly as prescribed. Taking more than the recommended dose may cause nausea, vomiting, diarrhoea, stomach pain, headache, dizziness, or weakness. In some cases, overdose may affect the liver, kidney function, especially in people with existing medical conditions.

If an overdose is suspected or symptoms become severe, seek medical attention immediately.

If you miss a dose of this antibiotic, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for it. Try to take doses at evenly spaced intervals, as missing doses can reduce effectiveness and may contribute to antibiotic resistance.