Naftifast Cream 50gm contains Benzyl Alcohol and Naftifine Hydrochloride, a topical fixed-dose combination used in the treatment of fungal skin infections. Benzyl Alcohol acts primarily as a preservative and local antimicrobial agent with mild soothing properties, while Naftifine Hydrochloride is a synthetic allylamine antifungal that inhibits fungal cell membrane synthesis by blocking ergosterol production. Together, they help control fungal growth, relieve itching, scaling, and redness, and promote healing of infected skin areas. This combination is commonly prescribed for superficial fungal infections such as athlete’s foot, ringworm, and jock itch. Always use Naftifast Cream 50gm exactly as directed by your doctor.
Written by: Syed Jommy Abbas, B. Pharma
Reviewed by: Dr. Devika Rani, MBBS
Last updated on: 07-05-2026
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Naftifast Cream 50gm contains Benzyl Alcohol and Naftifine Hydrochloride, a topical fixed-dose combination used in the treatment of fungal skin infections. Benzyl Alcohol acts primarily as a preservative and local antimicrobial agent with mild soothing properties, while Naftifine Hydrochloride is a synthetic allylamine antifungal that inhibits fungal cell membrane synthesis by blocking ergosterol production. Together, they help control fungal growth, relieve itching, scaling, and redness, and promote healing of infected skin areas. This combination is commonly prescribed for superficial fungal infections such as athlete’s foot, ringworm, and jock itch. Always use Naftifast Cream 50gm exactly as directed by your doctor.
Naftifast Cream 50gm contains Benzyl Alcohol and Naftifine Hydrochloride, a dual-action topical dermatological preparation designed for the treatment of superficial fungal infections of the skin. Naftifine Hydrochloride belongs to the allylamine class of antifungal medicines and exerts potent fungicidal activity by inhibiting squalene epoxidase, an essential enzyme involved in ergosterol biosynthesis. Ergosterol is a critical structural component of fungal cell membranes, and its depletion leads to fungal cell membrane instability and eventual fungal cell death.
Naftifine is effective against dermatophytes such as Trichophyton, Microsporum, and Epidermophyton species, and also shows activity against certain yeasts and moulds. In addition to antifungal action, Naftifine possesses anti-inflammatory properties that help reduce redness, itching, and irritation associated with fungal infections.
Benzyl Alcohol serves as a preservative and mild antimicrobial component in the formulation. It also contributes to local soothing and helps maintain formulation stability.
The combination offers both targeted antifungal treatment and symptomatic relief, making it useful in fungal infections affecting moist and friction-prone areas of the body. Naftifast Cream 50gm is available as a cream, gel, or topical solution for external use only and should be applied regularly for the full prescribed duration even if symptoms improve early.
The uses of Naftifast Cream 50gm are as follows:
Treatment of fungal infection affecting the feet and toe spaces.
Management of circular fungal lesions on the body.
Treatment of fungal infection affecting the groin area.
Control of fungal skin infections caused by dermatophytes.
Helps relieve discomfort associated with fungal lesions.
Useful in infections between fingers or toes.
Here are the benefits of Naftifast Cream 50gm:
Like all medicines, Naftifast Cream 50gm may cause side effects in some individuals, although many people tolerate it well. Most side effects are mild and temporary.
To ensure optimal benefit and minimise irritation, Naftifast Cream 50gm should be used exactly as advised by your doctor.
Naftifast Cream 50gm works through complementary antifungal and supportive topical actions.
Naftifine Hydrochloride inhibits squalene epoxidase, blocking ergosterol synthesis in fungal cells. This causes toxic intracellular squalene accumulation and disruption of fungal cell membrane integrity, leading to fungal cell death.
Benzyl Alcohol contributes local antimicrobial support and formulation preservation, helping maintain local skin cleanliness and reducing microbial contamination.
Together, the combination reduces fungal burden, controls inflammation, and improves local symptoms.
Naftifast Cream 50gm does not have significant food interactions because it is used topically. However:
Benzyl Alcohol + Naftifine Hydrochloride may interact with:
Naftifast Cream 50gm should be used carefully in:
The dose depends on the severity and site of infection. Usually, a thin layer is applied once or twice daily as prescribed. Continue for the full treatment course even if symptoms improve early.
If you miss an application, apply it as soon as you remember unless it is nearly time for the next application. Do not apply extra medicine to make up for the missed dose.
Therapeutic Class
Dermatology / Antifungal
Action Class
Topical Antifungal
Chemical Class
Aromatic Alcohol + Allylamine Antifungal
Habit Forming
No
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