Drep O Ear Drop 5ml

The external ear canal has a slightly acidic, lipid-rich environment that resists colonisation. When this environment is disturbed by water, trauma, eczema, or excess wax, bacteria and fungi can proliferate and cause otitis externa, which is often acutely painful.

Glacial acetic acid is highly concentrated acetic acid; when diluted within an ear drop formulation, it lowers the pH of the ear canal back towards its natural acidic state. This pH change is unfavourable for many bacteria and fungi, and helps slow their growth. Lidocaine blocks voltage-gated sodium channels in sensory nerve endings, preventing transmission of pain signals from the inflamed canal lining, thereby reducing pain and itch within minutes. Ofloxacin is a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication. It has broad activity against organisms commonly implicated in otitis externa, including Pseudomonas aeruginosa and Staphylococcus aureus. Together, the three components address infection, environment, and symptoms in a single preparation.

• To treat acute bacterial otitis externa (outer ear canal infection) with associated pain.

• To provide relief for ear pain and itch during topical antibacterial treatment.

• As prescribed by a healthcare professional after examination of the ear.

• Rapid pain relief due to lidocaine's local anaesthetic action.

• Targeted topical antibacterial activity against common ear canal pathogens with ofloxacin.

• Restoration of the natural acidic pH of the ear canal by acetic acid.

• A single multipurpose drop simplifies the treatment regimen.

Common

• Mild stinging or burning in the ear on instillation
• Itching or temporary numbness of the ear canal
• Unpleasant taste at the back of the throat

Uncommon

• Local rash or contact dermatitis
• Headache or dizziness
• Worsening of ear discharge (in some cases)

Serious side effects requiring immediate attention

• Severe allergic reaction, which may manifest as swelling of the face or throat and difficulty breathing
• Hearing loss, severe dizziness, or persistent ringing in the ear
• New or worsening ear discharge after a few days of use

Warm the bottle of Drep O Ear Drop 5ml briefly between your palms to bring the drops to body temperature, as cold drops can cause dizziness. Tilt your head so the affected ear faces upwards. Gently pull the ear upwards and backwards (downwards and backwards in young children) to straighten the canal. Instill the prescribed number of drops, then keep the head tilted for a few minutes so the medicine spreads through the canal. Do not insert cotton plugs unless your doctor advises you to. Wipe excess from the outer ear. Wash your hands after use. Use for the duration prescribed, usually a short course.

A healthy ear canal is slightly acidic, and this natural acidity helps limit the growth of bacteria and fungi. When the canal becomes inflamed or infected, its pH often rises towards neutral, which is more favourable for many of the organisms involved in otitis externa. Acetic acid restores the canal's acidic pH. In this acidic environment, the growth and metabolism of many bacteria and fungi are disrupted, helping reduce microbial load alongside the antibiotic.

When the lining of the ear canal is inflamed, the endings of the sensory nerve fibres fire and send signals to the brain, which is perceived as pain or itching. For a nerve to fire, sodium must flow into the cell through tiny channels called voltage-gated sodium channels. Lidocaine binds to the inside of these channels and blocks them. Without sodium entry, the nerve cannot fire, the signal does not reach the brain, and the area feels numb. Because the drops are applied directly to the inflamed canal, relief begins within minutes and is limited to that local area.

Bacterial DNA is normally tightly coiled, and the cell relies on two enzymes to uncoil and re-coil it during replication: DNA gyrase (the main target in gram-negative bacteria such as Pseudomonas) and topoisomerase IV (the main target in gram-positive bacteria such as Staphylococcus). Ofloxacin enters the bacterial cell and inhibits both enzymes, leaving the DNA stuck mid-process. The bacterium can no longer replicate or repair its DNA and dies. Because the drops act directly on the infected canal, ofloxacin reaches high concentrations at the site of infection with minimal absorption into the rest of the body.

Together, the three components address different aspects of an infected, painful ear canal: acetic acid restores an unfavourable environment for the organisms, ofloxacin kills the bacteria, and lidocaine relieves the associated pain.

No clinically significant food interactions are reported for topical otic use.

• Other ototopical preparations (CAUTION): Avoid combining without medical advice.

• Systemic fluoroquinolones (CAUTION): When already on oral or IV fluoroquinolones, inform your doctor. While systemic absorption is minimal, it should be noted.

• Class I antiarrhythmics or other local anaesthetics (CAUTION): Additive effects are not significant with topical otic use but should be disclosed.

• Perforated tympanic membrane or ear tubes (CAUTION): Acetic acid can be irritating to middle ear structures. Many otic acidic preparations are not recommended when the eardrum is not intact.

• Otomycosis (fungal ear infection) (CAUTION): Fluoroquinolone use without antifungal cover may not adequately treat a primarily fungal infection.

• Recurrent or chronic otitis externa (CAUTION): Requires medical review to exclude diabetes, immunocompromise, or malignant otitis externa.

• Diabetes (CAUTION): Increased risk of severe or malignant otitis externa, which involves infection of the bones of the ear canal and at the base of the skull. Hence, medical follow-up is important.

Overdosing on topical ear drops is rare. However, accidental ingestion of large amounts of Drep O Ear Drop 5ml can cause systemic effects from lidocaine, which often include dizziness, drowsiness, tremor, and irregular heartbeat and gastrointestinal irritation from acetic acid. Seek medical advice if accidental ingestion occurs.

If you miss a dose, instil it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose and continue. Do not double the dose.